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Best Selling Vitamins in the Industry

For decades, there has been an increase in demand for nutraceutical and dietary supplements. Before the pandemic, this increase was slow but steady.

When the pandemic struck, supplement sales went out the roof. In March 2020, supplement sales in the United States rose over 50% compared to 2019. Even though society has begun to return to normal, experts predict the supplement industry will continue to grow. Fortune Business Insights expect the industry will reach a market size of USD 128.64 billion by 2028 (compared to USD 61.20 billion in 2020).

Even with demand increasing, not every supplement will be a market success.

Many factors affect the success of a supplement. The most important factor is what kind of supplement you are trying to sell. It’s critical when designing a supplement that you consider what is currently marketable and the reliable research backing consumer desired effects.

The most popular supplements can be categorized as follows: immune support, stress relief, beauty products, fitness, and pet nutrition.

Immune Support

The success of immune support supplements has bolstered the nutraceutical industry in the past few years. With a worldwide pandemic on our hands, it’s no wonder people are interested in something that can help protect their health.

Many top immune support supplements contain zinc, Vitamin C, Vitamin D, and B Vitamins.

  • Zinc Mineral deficiencies, including zinc deficiency, are becoming more common. The size of the mineral supplement market in 2018 was USD 10.26 billion. More than 300 enzymes in the body require zinc to perform their biochemical roles. Studies show zinc is essential to the production or maintenance of numerous parts of the immune response system, including peripheral T-cell and thymocyte count, T-cell proliferation and activity, and macrophage and neutrophil functions. Zinc supplementation has a positive impact on several different illnesses and diseases. Studies show zinc reduces the duration of the common cold, bacterial infections, and symptoms of Rheumatoid arthritis, Parkinson’s disease, Sickle Cell Disease, AIDS, and other illnesses. Zinc supplementation is crucial for older people. Zinc levels decline with age, and supplementation can help boost the immune system and decrease age-related inflammation.

  • Vitamin C The worldwide market for Vitamin C is predicted to grow by 4.8% in the next five years. Vitamin C could likely fit under almost any supplement support category in this article; it’s one of the best vitamins to include in a supplement. It plays roles in synthesizing macromolecules like collagen and neurotransmitters, absorbing iron from plants, and handling oxidative stress, protein metabolism, and proper immune system functions.

Due to its antioxidant properties, studies are currently examining if Vitamin C may decrease the likelihood of developing diseases associated with oxidative stress, such as cancer and cardiovascular disease. One study showed that plasma concentrations of Vitamin C in those with cancer are lower than in control subjects. People who are most likely to be vitamin C deficient (and thus most likely to benefit from supplementation) are smokers, those with chronic diseases, and older people.

  • Vitamin D The Vitamin D market is expected to grow by 7.2% by 2025. Even though the body naturally produces Vitamin D from exposure to sunlight, people often supplement it because of the growing concern of damaging ultraviolet rays. Vitamin D has biochemical roles in metabolism, growth, inflammation reduction, and maintaining the integrity of the immune and neuromuscular systems. Vitamin D and calcium supplements often go hand in hand since Vitamin D is required for the body to absorb calcium. Vitamin D is critical for older people developing osteoporosis. More than 53 million US adults have or are at risk of osteoporosis. In 2015, 2.3 million osteoporosis-related fractures occurred in the United States alone. Some studies indicate Vitamin D and Calcium supplementation increase bone density and reduces the fracture rate of institutionalized older adults. Other studies show no correlation. Data collected (from 2013 to 2016) by the National Health and Nutrition Examination Survey (NHANES) found 94% of all people over age one consumed less than the daily recommended amount of Vitamin D. Keep in mind people living between 34° North and South latitudes obtain appropriate levels of Vitamin D from sunlight, but there is a giant market for Vitamin D supplements.

  • B Vitamins B vitamins are so crucial to healthy functioning that, like Vitamin C, it fits under most supplement support categories. B Vitamins are expected to be a top-selling supplement by 2024. B vitamins are essential for the nervous system, red blood cells, and metabolism functioning. Their role in cell metabolism makes B Vitamins a common additive to energy drinks. They’re critical for protein production and maintaining cell selenocysteine levels. Symptoms of B-complex vitamin deficiencies are anemia, depression, a weakened immune system, dermatitis, neurological symptoms, and more. Certain illnesses and conditions make it more likely that someone will be vitamin B deficient. Older people and those with gastrointestinal or autoimmune disorders are at a greater risk of having a Vitamin D deficiency.

Beauty Products Many Americans are spending money to appear younger and more attractive. Successful beauty supplements often include fish oil and collagen peptides.

  • Fish Oil For people over age 65, fish oil is the most used non-vitamin or mineral supplement. Fish oil could also fit in the immune support category. Studies show that supplementation can help treat rheumatoid arthritis, cancer, cardiovascular disease, depression, asthma, Parkinson’s disease, diabetes, and more. However, fish oil is also used to treat skin diseases such as photoaging, skin cancers, hyperpigmentation, and otherwise damaged skin. Research shows fish oil improves skin function, prevents inflammation caused by ultraviolet rays, accelerates skin repair, and prevents skin cancer. And according to researchers, these benefits come about regardless of the administration route (oral, topical, etc.). There is room here to be creative with a fish oil supplement.

  • Collagen Peptides Collagen maintains the health of skin, joints, connective tissue, and bones. By age 40, people lose about 1% of their bodily collagen each year. As we lose collagen, our joints become stiff, we lose muscle mass, and we develop wrinkles. Collagen peptides supplementation may retard collagen loss. Studies show that collagen peptides can keep the skin hydrated (staving off wrinkles), combat joint pain, and strengthen bones and muscles. There is some controversy about the effectiveness of collagen peptide supplements. However, experts expect the global market to reach USD 2.8 billion by 2027.

Stress Relief

According to the American Psychological Association (APA), more than 75% of adults surveyed in 2019 reported symptoms of stress such as headaches, exhaustion, and problems sleeping. And 2020 did nothing to alleviate the pressure on anyone.

It is projected that the mental health and brain supplement market alone will grow at 8.5% over the next six years.

Ingredients such as magnesium and B vitamins are the most popular and common mental health supplements.

  • Magnesium It would be inappropriate to create a list of top-selling supplements without including magnesium. Magnesium is an essential cofactor for DNA replication and RNA transcription. The body’s cells cannot divide or produce proteins without it. Proteins are necessary to metabolize food, support muscle and nerve function, and more. A study examining the popularity of different supplements by analyzing google search trends found that magnesium was by far the most googled searched supplement. Since magnesium deficiencies are becoming more common (48% of Americans daily consume less Mg than needed), Magnesium is one of the fastest-growing mineral supplement markets.


Athletes and fitness enthusiasts need the best nutrition to see optimal improvement in performance. Most of these people will turn to supplements to ensure they have everything they need to power what they love. According to the NIH, a larger proportion of athletes than the general US population take dietary supplements.

Sports nutrition supplements often contain creatine and protein.

  • Creatine Creatine supplementation began in the 1800s, though it didn’t become popular until 1992. Now, it is a well-liked athletic supplement. In 2014, the NCAA reported that creatine was the most commonly used supplement for male baseball, football, ice hockey, and lacrosse players. Even though professional athletes love it, creatine is also popular among high school and college athletes, everyday gym-goers, and military members. Creatine is involved in processes that make ATP readily available in cells. No wonder it is an athlete’s go-to. Long-term creatine supplementation has been shown to lead to 5-15% greater gains in performance (including swim, sprint, and power), body mass, carbohydrate storage, and workout recovery.

  • Protein By 2027, the protein powder market is expected to reach USD 30.5 billion. A study on young athletes found that over 50% took whey protein powder supplements. It makes sense. Most people comprehend muscles need protein. Logically, if you want to get stronger, you must consume enough protein to build muscle.

Studies show protein supplementation can facilitate muscle recovery, gains, and performance in all types of athletes. As the intensity (volume, frequency, duration, etc.) of resistance training increases, protein supplementation becomes more beneficial to the athlete. There are many sources of protein supplements. Whey is very popular, although so are many other milk-based and plant-based protein powders. Each has its bonuses and pitfalls. If you’re designing a protein supplement, you will want to think about the best protein source for your niche market.

Pet Nutrition

People love their animals. In 2021, the APPA (American Pet Products Association) reported that in the U.S. alone, dog, cat, and bird owners spent a total of USD 109.6 billion on their animals. That’s a lot of money!

Animals have as many dietary needs as we do. Most pets should receive supplements to reduce the risk of diseases, fight off common issues such as allergies and bacterial infections, and generally maintain optimal health.

Animal and pet supplementation brings more things to consider during the design process. For example, it is probably a good idea to make a pet supplement something that’s chewable or in powder form. Animals do not swallow pills or tablets well, and you want supplementation to be as easy as possible for the owner.

Origin Nutraceutical

This is only a taste (pun intended) of the endless supplement possibilities. This article would be a mile long if we tried to discuss all of the most popular supplements because there are so many of them!

Current and future nutritional supplement industry trends are favorable for brand owners and entrepreneurs. Now is the best time to design your supplement and take advantage of the growing supplement market!

Origin Nutraceutical is one of the best supplement manufacturers in the US. We are GMP (Good Manufacturing Practices) certified by NSF International. Our Research and Design (R&D) team aids inspired people to produce marketable supplements; we can help you, too. All of our products are proudly made in the USA. We work side by side with you to optimize the manufacturing process to produce a successful, highly marketable supplement.

Contact us today to turn your supplement ideas into reality.

The content of Origin Nutraceutical’s website is for information only, not advice or guarantee of outcome. Information is gathered and shared from reputable sources; however, Origin Nutraceutical is not responsible for errors or omissions in reporting or explanation. No individuals, including those taking Origin Nutraceutical products, should use the information, resources or tools contained within to self-diagnosis or self-treat any health-related condition. Origin Nutraceutical gives no assurance or warranty regarding the accuracy, timeliness or applicability of the content.

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Davidson, Katey. “The Top 7 Vitamin and Supplement Trends of 2021”. Healthline. 2021.

“Top-Selling Supplements in the Industry”. MBi Nutraceuticals. 2019.

Rink, Lothar. “Zinc and the Immune System.” Proceedings of the Nutrition Society. 2007.

Haase, Hajo; and Rink, Lothar. “The Immune System and the Impact of Zinc During Aging”. NIH. 2009.

Single Care Team. “Stress Statistics 2022: How Common Is Stress and Who’s Most Affected?”. The Check Up. 2022.

“Dietary Supplements for Exercise and Athletic Performance”. NIH. 2021.

Baginski, Caren. “What are the top selling and fastest growing mineral supplements?”. New Hope Network. 2017.

Kaminski, Mikolaj; et. al. “Determination of the Popularity of Dietary Supplements Using Google Search Rankings”. NIH. 2020.

“Magnesium”. NIH. 2022.

“Vitamin C”. NIH. 2021.

Kreider, Richard B. “Creatine in Sport”. ATM Health and Kinesiology. 2020.

Butts, Jessica. “Creatine Use in Sports”. NIH. 2018.

Pasiakos, Stefan M et al. “The effects of protein supplements on muscle mass, strength, and aerobic and anaerobic power in healthy adults: a systematic review.” Sports medicine. 2015.

Cintineo H.P., Arent M.A., Antonio J., Arent S.M. “Effects of Protein Supplementation on Performance and Recovery in Resistance and Endurance Training”. NIH. 2018.

Jovanov, P., Đorđić, V., Obradović, B. et al. “Prevalence, knowledge and attitudes towards using sports supplements among young athletes”. J Int Soc Sports Nutr. 2019.

“Protein market to hit $30.5 billion by 2027, Says Global Market Insights, Inc.” Global News Wire. 2021.

“Pet Supplements Market Size, Share & Trends Analysis Report By Pet Type (Dogs, Cats), By Form (Pills, Chewable powders), By Application, By Distribution Channel, (Online, Offline), By Region, and Segment Forecasts, 2022-2030.” Grand View Research. 2022.

“Vitamin B6”. NIH. 2021.

“Vitamin B12”. NIH. 2022.

“Vitamin D”. NIH. 2021.

Huang, Tse-Hung et al. “Cosmetic and Therapeutic Applications of Fish Oil's Fatty Acids on the Skin.” Marine drugs. 2018.

“Omega 3-Fatty Acids”. NIH. 2021.

“Everything you should know about collagen peptides”. HealthEssentials.2 2021.

“Global Collagen Peptides Market Segmented by Source (Pigskin, Cattle Hide & Bones and Poultry & Fish), by Application (Nutritional Products, Snacks & Cereals, Beverages, Dairy Products, and Meat & Poultry Products) and by Regional Analysis (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast (2022 – 2027)”. Market Data Forecast. 2022.

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